Therapeutic strategies, including a high surgical ligation rate: RESULTS (part 1)

24 Jul
2012

Patient population
Among the 656 infants of 23+0 to 26+6 weeks’ gestational age admitted within the study period, 253 were eligible based on the inclusion criteria. Fifty-seven cases were excluded (23 due to absence of echocardiographical confirmation of PDA; 20 due to incomplete data related to PDA management; 11 due to death within the first seven days of life [six due to grade 3 or 4 intraventri-cular hemorrhage and extreme prematurity; three due to sepsis; two due to extreme prematurity]; two due to congenital heart lesion; and one due to a genetic disorder) resulting in a cohort of 196 (Table 1). You have a great opportunity to discover the pharmacy that will always be sure to live up to your highest expectations, no matter if you would like to get cialis discount or buy any other prescription medicine with no prescription required on very advantageous terms.

 TABLE 1 Demographic and clinical information for infants with a patent ductus arteriosus (PDA) at 23+0 to 26+6 weeks’ gestational age

Characteristicn=196
Birth weight, g, median (range)782 (355-1300)
Gestational age weeks, median (range)25 (23-26)
Female90 (46)
Antenatal steroids*112/181 (62)*
Respiratory distress syndrome*168 (86)
Small for gestational age3 (2)
Inotropes§41/194 (21)*
Age at diagnosis of PDA,5 (1-32)
days, median (range)
Age at first treatment of PDA,5 (1-43)
days, median (range)
Mortality41/192 (21)*
Sepsis^129/195 (66)*
Severe intraventricular hemorrhage**32/194 (16)*
Necrotizing enterocolitis**29/194 (15)*
Severe renal dysfunction**25/195 (13)*
Retinopathy of prematurity§§56/140 (40)*
Chronic lung disease^98/139 (70)*
Home on oxygen36/129 (28)*
Time on ventilator, days, median (range)32 (1-148)
Time to discharge, days, median (range)103 (50-420)

*Data given as n (%), unless otherwise indicated. *Two doses of betamethasone 12 h to 24 h apart before delivery; fThe denominator reflects the number of infants for whom the outcome was possible, those lost to follow-up and those where the information was not documented; *Received surfactant. §Used for hypotension and/or myocardial dysfunction considered related to PDA; HBlood culture proven. **Grade 3 or 4 intraventricular hemorrhage; ffModified Bell criteria stage 2A or greater; &Serum creatinine levels >150 ymol/L, and/or a urine output <0.6 mL/kg/h for >12 h; §§Threshold or prethreshold disease requiring laser surgery (>31 weeks’ corrected gestational age); ^Radiological changes with oxygen requirements or invasive or nonin-vasive ventilation at >36 weeks’ corrected gestational age.

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