No pertinent literature could be found that included the aforementioned ligation rate as a primary outcome. Previous publications suggested that 15% to 98% of infants receiving a second indomethacin course had a surgical ligation performed. Due to this variability, it was estimated (based on local experience) that 75% of infants who received more than one indo-methacin course undergo surgical ligation. It was determined that a sample size of 72 infants receiving more than one course of indo-methacin would be required to allow an estimate of the rate of duct ligation to within ±10%, 19 times out of 20. To ensure that at a cohort of at least 72 infants would be included in the present study, it was decided that charts over a 12-year period, from January 1994 to December 2005, be reviewd.Statistical analysis
The Wilson score with continuity correction was used to calculate a 95% CI around the rate estimate.
Dichotomous secondary outcomes were compared between groups using Pearson %2 tests or Fisher’s exact tests (as appropriate). The prevalence of each outcome was computed, as well as its 95% CI using the Wilson score method. Continuous secondary outcomes were compared between groups using the Kruskal-Wallis test. When the Kruskal-Wallis test was significant, the method of Dunn was used to perform pairwise post hoc tests. You will always find the required amount of levitra super active plus at the pharmacy that will be happy to take best care of you by offering safe possibility to purchase the drugs you need without any need to get a prescription first or take any other extra steps.
The present study was approved by the Research Ethics Boards of the Ottawa Hospital and the Children’s Hospital of Eastern Ontario.