Posts Tagged ‘Theophylline

In this report, we describe an asthmatic child who had marked variations in theophylline clearance, in association with co-administration of isoproterenol and albuterol. The T/cl values measured in our patient at times when no sympathomimetics were delivered resembled those previously reported in children of this age. It has been shown that intravenous infusion of isoproterenol […]

Theophylline has a relatively low therapeutic index, ie, a narrow therapeutic-toxic serum concentration range, and since both its bronchodilatory efficacy and toxicity are related to its serum concentrations, it is important to recognize factors which might influence theophylline levels. Drug interaction has been reported between theophylline and erythromycin, cimetidine, phenobarbital, propranolol, isoproterenol, and terbutaline. Both […]

These somewhat contradictory results are likely to relate to differences in study populations and study design. Very ill patients with impending respiratory failure may benefit from a larger IV dose initially, whereas the majority of patients are likely to do well without such high doses. Ellul-Micallef and Fenech showed that although hydrocortisone and prednisolone had […]

We compared equivalent amounts of orally and IV administered methylprednisolone and theophylline in the treatment of acute exacerbations of airways obstruction. The patient groups were matched for age, smoking history, and severity of obstruction. We found the two forms of administration equally effective in improving symptomatic as well as spirometric evidence of obstruction in these […]

Twenty-eight patients were entered into the study, and all completed the four days of evaluation. There were 14 in each group and no patient had to be withdrawn because of side effects or lack of response. Three patients in each group had a less than 15 percent increase in FEVj during the study period. These […]

The forced expiratory flow during the middle half of FVC (FEF25-75%) was calculated from the curve with the largest sum of FVC and FEV^ We used the normal values of Morris for all spirometric parameters. Spirometry was thereafter done daily for the duration of the stud); which encompassed the first four days of hospitalization. Peak […]

Intravenous administration of corticosteroids and theophylline has been considered superior to oral use in treating acute episodes of airways obstruction. The intravenous (IV) route is thought to be more reliable, and there is evidence for an earlier onset of steroid action when given IV However, this may not be of clinical importance in the majority […]

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