Posts Tagged ‘Receptor Expression

Thus, in addition to loss or attenuation of ligand-dependent ER activity, uterine hypoplasia in ERKO mice and endometrial hypoplasia in neonatal gilts treated with ICI 182,780 could reflect the uncoupling of ligand-independent ER signaling systems. These data also imply that the presence of a functional ER system may enhance the ability of target cells to […]

The technology required to produce the ERKO condition is not currently available for large domestic ungulates. However, when compared to findings for vehicle-treated controls, administration of the antiestrogen ICI 182,780 to neonatal pigs from birth reduced both endometrial thickness and uterine gland penetration depth on PND 7 and PND 14. These antiuterotropic effects of ICI […]

In that study, appearance of endometrial glands was associated with a dramatic and specific increase in [methyl-3H] thymidine labeling by GE cells, whereas LE labeling actually decreased. The fact that endometrial GE cells develop ER before LE cells in the neonatal porcine endometrium is in contrast to patterns reported for the mouse and rat. However, […]

ER-positive cells also develop in endometrial epithelium of mice and rats postnatally. Immunohistochemical detection of ER in CD-1:CRL and CD-1[1CR]BR mice revealed that stromal cells were strongly ER positive on Day 1 (birth), while uterine epithelium was only weakly positive by PND 4. However, different strains of mice exhibit different developmental expression patterns for ER. […]

While, in general, endometrial ER expression patterns changed positively in association with age, OVX of gilts at birth did not affect patterns of endometrial ER mRNA and protein expression. Therefore, mechanisms regulating acquisition of ER-positive phenotype by porcine endometrial cells between birth and PND 120 are developmentally regulated, but ovary independent. Because uterine tissues were […]

The extent to which contributions from the adrenals may ultimately affect patterns of uterine growth between birth and puberty in the pig remains unclear. However, Evans et al. found no clear relationship between patterns of adrenal or thyroid gland growth and gross aspects of reproductive tract growth in gilts between weaning, at 3 wk of […]

The results indicate clearly that OVX at birth did not affect porcine uterine growth or endometrial morphogenesis between birth and PND 60. Thus, uterine growth and endometrial development during this period are ovary-independent phenomena. In contrast, uterine growth from PND 60 to PND 120 is ovary dependent. Results are consistent with those reported by Wu […]

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