Posts Tagged ‘propofol emulsion

Previous work describing the compatibility of a mixture of ketamine and propofol in a 50:50 ratio, using a reformulation of the original product containing EDTA, reported that the combination was stable for up to 1 h at room temperature. Another study,12 which used the original formula­tion (without EDTA), reported the formation of globules after h. […]

There was no significant change in the pH of either solution after 1 or 3 h of storage at room temperature and exposure to light. The average pH of the 50:50 mixture was initially 4.98 and was nearly the same (4.99) 3 h later. For the 30:70 mixture, the average pH was 5.16 initially and […]

Sample Preparation Propofol 1% emulsion (10 mg/mL; Novopharm Ltd, Toronto, Canada, lot 06K325, expiry August 2008) was combined in a ratio of either 50:50 or 70:30 with ketamine solution (10 mg/mL; Sandoz Inc, Boucherville, Quebec, lot 132425). Ten-millilitre samples of the mixture were then trans­ferred to each of three 20-mL polypropylene syringes (Becton Dickinson and […]

INTRODUCTION Procedural sedation and analgesia for painful procedures is the standard of care in emergency medicine. The ideal agent for procedural sedation and analgesia should be safe and easy to administer, should provide analgesia and amnesia with rapid onset, and should allow quick recovery and cause a minimum of adverse effects. Common agents include propofol, […]

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