Posts Tagged ‘Peptic ulcer disease

Infection with H pylori appears to be implicated in several upper gastrointestinal disorders. However, the incidence of H pylori infection in the general population is high; thus, widespread testing for H pylori is inappropriate. Selection of patients for whom presence of H pylori should be tested remains controversial. It is clear that eradication of H […]

There is strong evidence to suggest that infection with H pylori is implicated in low grade gastric MALT lymphomas. Eradication of H pylori in patients with gastric MALT lymphoma results in complete resolution of disease in most cases; therefore, the Canadian Consensus Guidelines recommend eradication of H pylori in all confirmed cases of this type […]

Possibly the most controversial issue of H pylori infection in gastrointestinal disorders is that of its relationship to GERD. The occurrence of de novo GERD following eradication of H pylori in patients with peptic ulcer disease has been observed in several reports, including a trial that prospectively examined the incidence of GERD in patients who […]

Investigation into whether eradication of H pylori improves the symptoms associated with functional dyspepsia has provided interesting results. In a large, multicentre study conducted by Blum and colleagues, 328 patients with functional dyspepsia and confirmed infection with H pylori were randomly assigned to receive one week of eradication therapy with a PPI plus amoxicillin and […]

Dyspepsia, characterized by pain and discomfort centred in the upper abdomen, is a common gastrointestinal complaint, with an annual prevalence of up to 40% in Western countries. However, a probable cause of dyspeptic symptoms is only evident in approximately 50% of cases. Thus, a high percentage of patients suffer from functional dyspepsia, defined as three […]

One of the more dangerous complications of NSAID-induced peptic ulcers is the risk of bleeding or perforation of the ulcer. A case controlled study evaluating the association of H pylori infection and bleeding peptic ulcers in current users of NSAIDs (including analgesic or antithrombotic doses of acetylsalicylic acid [ASA]) determined that NSAID users who were […]

NSAID use is implicated in approximately 10% to 30% of peptic ulcers, with an increased risk of ulcer in older NSAID users, patients with previous peptic ulcer, and patients who use steroids, high doses of multiple NSAIDs or anticoagulants. The role of H pylori in NSAID-induced ulcers is less clear, but some evidence exists to […]

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