A major limitation of this study was the impossibility of determining whether symptoms of toxicity were due to interactions between a prescription drug and digoxin or between a herbal supplement and digoxin. The numerous medications and supplements used and the variety of dosages and regimens confound the assessment of clinical effects due to herb-digoxin interactions. […]
Among the patients surveyed, there was no difference in the prevalence of herbal supplement use between those reporting and those denying symptoms potentially related to digoxin toxicity. Although the lack of a difference may be attributable to the fact that only a few patients were using herbal supplements purported to interact with digoxin, the general […]
Previous research on the frequency of use of alternative medications has focused on the general public or on cardiac patients in general. In this study, we examined the use of nonprescription medications within a specific subpopulation, patients who were taking digoxin. Because both dietary supplements (herbal and nonherbal) and OTC medications are commonly used, they […]
Use of Prescription Medications The mean number (± standard deviation) of prescription medications, including digoxin, taken during the month before the survey was 7.6 ± 2.8, and the number of concurrent prescription medications ranged from 1 to 17. Almost 90% of the patients (152 or 88.4%) had been exposed to one or more medications with […]
Patient CharacteristicsOf the 447 potential participants identified in the chart review, 143 could not be contacted, and 132 were excluded for various reasons: declined to participate in the study, were excluded by their doctors, lacked sufficient proficiency in English, were no longer taking digoxin, had died, were in poor health, or were deaf. A total […]
Data Collection The interviewer administered the survey (in person or by telephone), using a standardized questionnaire with questions about relevant exposures and symptoms during the month before the survey date. The questionnaire consisted mostly of checklists and fill-in-the-blank entries; the interview lasted about 10 to 15 minutes. Data collected included demographic characteristics, indication for digox- […]
Study Design and Setting This open-label, cross-sectional survey study was approved by the University of British Columbia/ Providence Healthcare Research Ethics Board. Patients receiving digoxin therapy were recruited at St Paul’s Hospital, Vancouver, British Columbia, a 500-bed urban teaching hospital.