Posts Tagged ‘Nitric oxide

In this study, we examined healthy male volunteers who were relatively young and had normal pulmonary function to evaluate the effect of smoking alone. We used the difference in NO concentration (ANO) as a parameter to determine the degree of airflow obstruction because it is a sensitive indicator of NO synthesis in the respiratory tract. […]

The two groups were age matched, and in both, pulmonary function was within the normal range, but FEVi o% and maximum expiratory flow at 25% and 50% vital capacity were significantly lower in smokers than in nonsmokers. In nonsmokers, the concentration of exhaled NO increased after breath-holding in a time-dependent manner (Fig 1). However, the […]

The experiments were approved by the human ethics committee of our university, and informed consent for participation was obtained from each subject. Nineteen healthy volunteers (all male) were allocated to two groups (Table 1): nonsmoking (n=9, mean [SE] 32.3 [3.4] years) and smoking (n=10,35.1 [1.7] years) subjects. Subjects with an asthmatic component, hypertension, or respiratory […]

Objective: The aim of this study was to examine the relationship between endogenous nitric oxide (NO) level and airflow obstruction in smokers using single-breath measurement of exhaled NO with the sequential breath-holding method. Setting: A university hospital. Patients: Nine nonsmoking and ten smoking healthy volunteers. Measurements: NO in exhaled air was measured using a chemiluminescence […]

Furthermore, although the release of nitric oxide through a signal from the ischemic myocardium may also explain part of the vasodilation observed during reactive hyperemia , it is well known that the increase in flow during reactive hyperemia is in excess of the oxygen debt established during the occlusion, as revealed by the persistence of […]

The changes in flow in the present experiments represent changes at the time of ischemia occurrence by a partial occlusion of a coronary artery, while those during reactive hyperemia correspond to changes at the time of repayment of flow after ischemia produced by the total occlusion of a coronary artery. Therefore, transmural flow distribution during […]

Our results show that the inhibition of nitric oxide synthesis produces a proportionally larger decrease of flow in the inner than in the outer layer of the ischemic left ventricular wall with a reduction of the I:O flow ratio below that observed by the effect of the sole ischemia. This result agrees with that of […]

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