This prospective randomized study did not support the hypothesis that low-dose ketamine and morphine, administered in combination, would result in less pain than morphine alone. In addition, the combination therapy was not associated with less nausea and vomiting or fewer psychotomimetic effects than morphine alone, and there was no difference in the total amount of […]
A total of 30 women enrolled and completed the study, 15 in each treatment group. There were no differences between the 2 groups with regard to age, height, weight, or body mass index (Table 1). None of the patients required PCA for more than 2 postoperative days. All of the patients were included in the […]
Before the hysterectomy procedure, each patient received ranitidine 150 mg orally. The general anesthetics thiopental and propofol were used for all patients. Rocuronium or vecuronium was used for muscle relaxation. A preoperative antibiotic, either cefazolin (1 g) or cefotetan (1 g), was given intravenously. PCA was started in the Post-Anesthetic Care Unit. The PCA device […]
The Pharmacy and Therapeutics Committee at the authors’ institution reviewed the protocol for this study, and approval was obtained from the Research Ethics Board. The study began in July 2001, and the original goal was to recruit 50 patients. However, in July 2002 the study was interrupted by a labour disruption and was never resumed.
INTRODUCTION Morphine is commonly used as an analgesic for the control of postoperative pain and is the “gold standard” against which all other analgesics are compared. Morphine acts mainly as an agonist at specific receptor sites in the central nervous system. Evidence suggests that both hyperanalgesic effects after tissue injury and opioid tolerance involve activation […]