Posts Tagged ‘fragmentation

Our success and mortality rates compare favorably with those of surgical pulmonary embolectomy, indicating that fragmentation therapy may serve as an alternative to surgery, if thrombolysis threatens to fail. They are also comparable with similar percutaneous procedures reported in the literature. For the catheter embolectomy procedure, Greenfield et al reported a 30-day survival rate of […]

Systolic and diastolic pulmonary artery pressure decreased slightly but significantly prefragmentation to postfragmentation. However, in average, there was no significant decrease of the mean arterial pulmonary pressure. This was mainly due to a case with only marginal angiographic improvement after fragmentation and two other cases with angio-graphically proven recanalization and decrease of shock index, but […]

Average degree of experimental recanalization of the pulmonary arteries was 53 ± 21%. In comparison, quantitative evaluation of the angiograms of the present clinical study showed an overall average percentage of recanalization prefragmentation to postfragmentation of 29.2 ± 14.0%, with exclusion of the three “unsuccessful” cases 36.0 ± 10.0%, respectively. While experimental results were obtained […]

However, the standard catheters used in the above-mentioned studies were not tailored for pulmonary arterial recanalization. A dedicated system may deliver better results. Following these considerations, we and others have spent a great deal of effort in the development of a pulmonary fragmentation catheter, favoring technically sophisticated solutions with high-speed rotating catheter tips, especially encaged […]

Patient 1 died from sepsis and multiorgan failure after the 48-h interval. A direct relation to residues of pulmonary embolism seemed unlikely, as a control angiography 6 days after fragmentation demonstrated completion of recanalization. Overall mortality was 20% (48-h mortality, 10%), overall treatment success accounted for 80%, including a patient with brain death (due to […]

The results of quantitative evaluation of the angiograms according to the angiographic severity index are given in Table 3. Its decrease prefragmentation to postfragmentation was highly significant (p < 0.001). According to the definition of fragmentation success, three cases were refractory to this therapy (No. 3,6,10), which is equal to a success rate of 70%. […]

Systolic and diastolic pulmonary artery pressure decreased significantly prefragmentation to postfragmentation (p = 0.03 and 0.01). Within the 48-h follow-up, significant decrease continued (p = 0.02 and 0.01). However, the decrease of the average mean arterial pulmonary pressure prefragmentation to postfragmentation was insignificant (p = 0.14), whereas it was highly significant within the 48-h follow-up […]