Posts Tagged ‘Central Cyanosis

Central cyanosis (blueness of skin, lips, mucous membranes), as opposed to peripheral cyanosis, is always a manifestation of hypoxemia. Except for the relatively uncommon causes of methemoglobinemia, sulfhemoglobinemia, and some hemoglobinopathies, central cyanosis is always accompanied by a low arterial Po2. As a result of hypoxemia an excess amount of hemoglobin is not saturated with […]

Of the ten original articles published after 1923, all but two reference the Lundsgaard and Van Slyke paper by footnote. Two of the ten articles erroneously compare an arterial value of RHB to the capillary value of Lundsgaard and Van Slyke. One review article also makes this erroneous comparison and as a result states that […]

“EVer since the discovery that incomplete oxygenation of arterial blood is the cause of central cyanosis, the question has been asked: How much reduced (deoxygenated or unsaturated) hemoglobin (RHB) is needed to generate central cyanosis? The amount commonly quoted, 5 g of RHB/dl of blood, comes from the classic 1923 monograph by Lunds- gaard and Van […]