Prostaglandin G/H Synthase (PGHS)-2 Expression in Bovine Myometrium: Influence of Steroid Hormones and PGHS Inhibitors(1)

18 Feb

PGHS Inhibitors(1)

The uterus is a complex organ composed of several cell types forming the myometrium and the endometrium. The successful outcome of the reproductive process requires a close collaboration between the different cell layers forming the uterus. Besides sex steroids, prostaglandins (PGs) appear as primary regulators of uterine functions during the entire reproductive cycle. The complex transformations affecting myometrial physiology during pregnancy require the liberation of such locally acting factors. canadian family pharmacy online

PGs may come from intrauterine tissues such as the placenta, but these structures may also metabolize PGs before they reach the myometrium. Because PGs primarily exhibit paracrine or autocrine actions, and because we have shown that the myometrium has its own profile of prostanoid production, we believe that this tissue may control its own functions through the production of specific PGs. Previous studies from our laboratory have demonstrated that cultured myocytes from the circular and longitudinal layers of bovine myometrium express distinctive properties, and more particularly, that there is a predominant production of prostacyclin (PGl2) by the longitudinal layer of bovine myometrium.