While increased expression of PGHS-2 in response to PMA is more evident in the longitudinal layer, Although we have not observed any modulation of PGHS-1 gene expression in the cyclic bovine myometrium, the role of this enzyme in the regulation of other reproductive processes such as parturition remains to be elucidated. There is good evidence demonstrating the importance of PGHS-1 in the maintenance of gestation in mice. Buy Advair Diskus Online
The availability of drugs that will selectively inhibit PGHS-1, in addition to the available PGHS-2 inhibitors, may contribute to a better understanding of the relative contribution of PGHS-1 and PGHS-2 isoforms to myometrial physiology. The present data clearly demonstrate that among the key enzymes involved in the biosynthesis of PG production, only PGHS-2 was responsive to steroid hormones. More interestingly, we indicated a double function of a specific PGHS-2 inhibitor acting both on the enzyme activity and on the enzyme expression. Taken together, these results suggest that a local regulation of myometrial PG production (via an up-regulation of PGHS-2), analogous to the local differential distribution of sex steroids evidenced in pregnant myometrium, may be instrumental in the study of uterine contractility regulation.