Necrotizing enterocolitis (NEC) is a common morbidity associated with high mortality in very low birth weight (BW) preterm infants. This population of infants has a high incidence of patent ductus arteriosus (PDA), and it has been suggested that the hemodynamic perturbation resulting from this condition is associated with higher risk of NEC.
We reviewed the literature to determine whether primary surgical closure (without prior indomethacin exposure) for treatment of a clinically and echocardiogram-identified PDA reduces the incidence of NEC, compared with treatment with indomethacin or exposure to prophylactic indomethacin in preterm infants <1500 g BW and/or <32 weeks’ gestation. If you want to make your online shopping advantageous and safe, check out the best pharmacy to buy here Xopenex Inhaler without any need for a prescription, any time of the day or night with straight to the doorstep delivery.
Key words selected with synonyms were: 1) “patent ductus arteriosus” OR “ductus arteriosus” OR “PDA”; 2) “preterm” OR “premature infant” OR “neonate” OR “newborn”; 3) “necrotizing enterocolitis” OR “NEC”; 4) “surgical ligation patent ductus arteriosus” OR “surgery patent ductus arteriosus” OR “surgery ductus arteriosus” OR “surgery pda”. These concepts were combined with the Boolean operator “AND”. Exclusion criteria were nonhuman subjects, non-English language, abstract only, review articles, children/adult subjects, >32 weeks’ gestation and >1500 grams BW.