Ovary-Independent Estrogen Receptor Expression in Neonatal Porcine Endometrium(2)

10 Jan

In the pig, endometrial glands are absent at birth but develop rapidly thereafter, forming coiled, branched epithelial tubes that extend radially from the luminal surface, through endometrial stroma, to the adluminal border of the myometrium by approximately PND 30. Intensely glandular folds of endometrium are apparent by PND 60. Events that accompany the appearance and proliferation of endometrial glands during this period include an abrupt, spatially focused increase in glandular, but not luminal, epithelial DNA synthesis, and alterations in the distribution and/or orientation of p-D-galactose and/or (3-TV-acetyl-D-galactosamine residues associated with glandular, but not luminal, epithelial cell surfaces. These developmental patterns suggest that uterine gland genesis in the neonatal pig involves local regulation of both cell proliferation and differentiation. asthma inhalers

Estrogen is uterotropic in the neonatal pig. Administration of estradiol-17p valerate (EV) to crossbred gilts for 7 days prior to hysterectomy on PND 7, 14, or 49 increased uterine wet weight and endometrial thickness, and altered patterns of uterine protein synthesis on all days.