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Furthermore, detachment of cells from the amnion is not an immediate death sentence since viable amniocytes can be collected from amniotic fluid, and limited digestion of amnion tissue with bacterial collagenase disperses cells that can be maintained in culture. Thus, the state of the amnion cells, the process leading to their separation from the matrix, or the duration of the separation may be key determinants of cell fate. flovent inhaler
Although the biochemical and structural changes that we have described in the rat amnion parallel to some degree changes that have been found in the human amnion, there are important differences between the rat and human membranes. For example, the rat amnion undergoes striking changes before labor that essentially encompass the whole amnion. In contrast, structural and biochemical changes in human fetal membranes appear to be restricted to specific regions near the rupture site. Unlike the human fetal membranes, the rat amnion is not adherent to a chorion laeve, so the nature of cellular communications in the rat and human fetal membranes could be substantially different. These and other differences must be considered by investigators attempting to extrapolate from studies conducted in rodents to humans.
In summary, the findings presented in this report suggest that the sequence of events involved in the terminal changes in amnion structure before onset of labor are initiated by increased MMP activity, leading to collagenolysis and, subsequently, to apoptotic death of amnion cells. This sequence predicts that detection of increased MMP activity could presage fetal membrane rupture.
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