LPP, a disease of unknown etiology, manifests as hyperpigmented, dark brown, occasionally pruritic macules and/or papules. The course of the disease is characterized by exacerbations and remissions. It is known to be more chronic than classical LP is.
With regard to the coexistence of classic LP in a number of LPP patients and the histopathological resemblance between these two disorders, many authors have suggested that LPP is a variant of LP.
However, classical LP shows a predilection for the wrist, thigh, ankle, and the dorsum of the hand, and to the best of our knowledge, there have been no reports of classical LP being confined to inter- triginous areas. The two current cases and the case detailed in our previous report confirm classic LP lesions confined to skin folds, which developed LPP features over time through epidermal flattening. canadian antibiotics
Although verification of similar cases is needed in order to confirm our hypotheses, we suggest that LPP-inversus may originate from LP of flexural areas. Furthermore, classic LP can be located in the flexural area only, so we suggest that a new term, ‘LP-inversus’, be used to designate such an entity.