Intravenous immune globulin: DISCUSSION(1)

1 Oct

Wide ranges of medical specialties, predominantly in hematology and neurology have used IVIG. Usage patterns, by indication of use have generally remained constant in both the adult and pediatric populations over the past three and two years, respectively.

Four indications (idiopathic thrombocytopenic purpura, chronic inflammatory demyelinating polyneuropathy, immune deficiencies and hypogammaglobulinemia) accounted for 72% of known usage in both patient groups. The top indications remained constant for each group over the years surveyed. Licensed use represented 47% in adults and 62% in pediatrics over the three- and two-year periods surveyed. The percentage of appropriate use for known indications over the three and two years in terms of grams of IVIG used was 87% in adults and 92% in pediatrics whereas future research use was 7% in adults and 3% in pediatrics.

A number of miscellaneous indications were reported that did not individually account for significant use. Within this miscellaneous use category (those indications that accounted for less than 1% of total annual IVIG use), 64% (27 of 42) were deemed to be inappropriate. All 27 of the miscellaneous indications that were categorized as inappropriate were prescribed to less than five patients each. This would suggest that sporadic attempts to treat difficult and or unfamiliar situations where no clear form of medical intervention has yet been established had occurred with IVIG. buy ampicillin