Exercise Response in Young Women with Borderline Hypertension: RESULTS

30 Mar
2011

Near-Maximal Physical Working Capacity (PWCl70) Mean PWC170 in BH patients was significantly lower than in the controls: 71 ± 23 W and 90 ± 17 W, respec­tively (p<0.001). Mean PWC170 did not differ signifi­cantly between symptomatic and asymptomatic BH patients: 72 ± 24 W and 69 ± 20 W, respectively.

Heart Rate and Blood Pressure

Mean heart rate, systolic and diastolic blood pres­sure, and pulse pressure levels at both rest and exercise were significantly higher in BH patients compared with the controls (Fig 1). Systolic blood pressure of >200 mm Hg at near-maximal exercise was found in 17 (10.8 percent) BH patients, but this level was not demonstrated among the controls (p<0.001). A raised diastolic blood pressure of ^90 mm Hg at near- maximal exercise was observed in 28 (17.8 percent) BH patients but not among the controls (p<0.001). A decrease in systolic blood pressure at near-maximal load below the resting value, or of not less than 10 mm Hg compared with the former workload, was observed in six (3.8 percent) BH patients, but it was not demonstrated among the controls (NS).

Mean heart rate, systolic and diastolic blood pres­sure, and pulse pressure levels, both at rest and at exercise, were not significantly different among symp­tomatic compared with asymptomatic BH patients. suhagra 100

FIGURE 1. mean heart

FIGURE 1. Mean heart rate, systolic and diastolic blood pressure, and pulse pres-sure levels at rest and exercise in 157 young females with borderline hyperten¬sion and in healthy controls. BPM = beats per minute.

In all the above parameters, the mean change between resting values and workloads of 50 W and 75 W was not significantly different among BH patients compared with controls (Fig 2).

Electrocardiogram

Arrhythmia at rest and/or at exercise test was found in 14 (8.9 percent) patients with BH as compared with three controls (2.9 percent); this difference was not statistically significant. Unifocal, isolated ventricular premature beats were found in nine BH patients (5.7 percent). Supraventricular premature beats were found in five BH patients (3.2 percent). Among the controls, ventricular premature beats were found in two subjects and supraventricular premature beats were found in one subject. The incidence of arrhyth­mia in both symptomatic and asymptomatic BH pa­tients was similar. There was no significant difference in the incidence of conduction disturbances between the BH patients and the controls.

Nonspecific ST and T wave changes at rest and at exercise test were more common in BH patients compared with the controls: these changes were observed in 34 (21.7 percent) patients and three (2.9 percent) controls (p<0.001) at rest, and in 64 (40.8 percent) patients and 24 (22.9 percent) controls (p<0.005) at exercise test. The changes were observed in leads 2,3, and aVF in 32 (94.1 percent) BH patients with ST-T changes at rest, and in 63 (98.4 percent) patients with ST-T changes at exercise test. The left precordial leads were the sites of these changes in ten (29.4 percent) patients with ST-T changes at rest, and in 20 (31.2 percent) patients with ST-T changes at exercise test. There were no instances when the ECG pattern was suggestive of ischemia. The inci­dence of ST-T changes both at rest and at exercise in asymptomatic and symptomatic BH patients was sim­ilar. Viagra Soft Tabs

FIGURE 2. Mean change

FIGURE 2. Mean change in heart rate, systolic and diastolic blood pressure, and pulse pressure levels at exercise test. BPM = beats per minute.

Mean corrected QT interval (QTC) was significantly longer in BH patients compared with controls (416 ±20 ms and 395 ± 17 ms, respectively, p<0.001). Prolonged QTC (>440 ms) was found in 19 (12.1 percent) of BH patients but in none of the controls (p<0.001). Mean QTC in symptomatic and asympto­matic BH patients was similar.

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