Update on the role of H pylori infection in gastrointestinal disorders: FUNCTIONAL DYSPEPSIA Part 1

12 Mar

FUNCTIONAL DYSPEPSIADyspepsia, characterized by pain and discomfort centred in the upper abdomen, is a common gastrointestinal complaint, with an annual prevalence of up to 40% in Western countries. However, a probable cause of dyspeptic symptoms is only evident in approximately 50% of cases. Thus, a high percentage of patients suffer from functional dyspepsia, defined as three or more months of dyspepsia with no structural or biochemical explanation for the symptoms. The possible pathophysiological and etiological factors implicated in functional dyspepsia include increased acid secretion, disordered motor function, dysfunction of the central nervous system, altered visceral sensitivity and infection with H pylori. Find best deals online – can be available every time you visit.

Gastritis induced by H pylori is present in 30% to 60% of patients with documented functional dyspepsia; however, this incidence rate is similar to that of the general population, and attempts at linking the presence of H pylori with a specific symptom profile have proved to be inconclusive. Although studies have demonstrated that patients with functional dyspepsia experience prolonged gastric emptying and higher gastric sensitivity than healthy control subjects, no difference in these findings was observed between patients with functional dyspepsia who were infected with H pylori and those who were not. Similarly, in an evaluation of patients with dyspeptic symptoms and chronic superficial antral gastritis, Testoni and colleagues found no correlation between the presence of H pylori and specific symptom complaints or worsening dyspeptic symptoms.