Gastric cancer: ENVIRONMENTAL RISK FACTORS AND H PYLORI Part 1

26 Mar
2012

Helicobacter pyloriRisk of gastric cancer is associated with socioeconomic status. Subjects from a lower socioeconomic class had approximately twice as much risk of developing intestinal-type gastric cancer as subjects from a higher socioeconomic group. On the contrary, proximal gastric cancers were associated with higher socioeconomic class. Cheapest treatment – buy levaquin 750 mg to always have a wide choice of options.

Large epidemiological studies demonstrating the association between diet and gastric cancer were mainly based on the amount of food imported and produced rather than the actual food consumption. This does not take into account the losses during storage, distribution and consumption of food, nor any ethnic dietary differences. The association between N-nitroso compounds and gastric cancer was summarized by Bartsch et al in 1987. The risk of gastric cancer induced by N-nitroso compounds has been demonstrated in animal experiments. An increase in gastric nitrite was observed in patients with intestinal metaplasia, dysplasia and gastric cancer. The use of nitrate-based fertilizers and pickled foods that contain nitrosated products has been shown to positively correlate with gastric cancer. High salt intake has been shown to damage stomach mucosa and increase the susceptibility to carcinogenesis in rodents. The positive correlation between nitrate intake, salt excretion and gastric cancer has recently been shown in the Intersalt study involving 24 countries from 39 populations.

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