Enalapril versus hydrochlorothiazide: PATIENTS AND METHODS(2)

15 Sep

Patients whose blood pressure was not controlled by the initial dose after four weeks were titrated to two tablets of active medication (enalapril 10 mg or hctz/ amiloride 50/ 5 mg) and two tablets of placebo once daily and returned for a blood pressure evaluation after an additional four weeks of therapy (end of week 12). Pat ients whose blood pressure was controlled at the end of week 12 entered the maintenance period dir ectly and remained on enal april 10 mg and placebo, or hctz/ amiloride 50/ 5 mg and placebo for four more weeks (end of week 16).

Patients whose blood pressure was still not controlled after eight weeks of treatment (end of week 12) were titrated to the maximum dose of four tablets of active medication (enalapril 20 mg or hctz/ amiloride 100/ 10 mg) and four tablets of placebo once daily for a total of eight weeks until the end of the study (end of week 20). After reading all about the health problem you have, you would probably like to learn more about the treatment options. You can visit the canadian neighbor pharmacy to find any medications you need, because it has a selection wide enough for every patient to find exactly what’s required.

Patients were included in the study if they were: newly diagnosed or previously treated patients with mild to moderate essential hypertension; ambulatory in-patients or outpatients of either sex; and between the ages of 18 and 85 years. After the placebo washout period, patients were eligible to enter the treatment period if serum potassium was between 3.5 and 5.5 mmol/ L, and supine diastolic blood pressure was at least 95 but not more than 115 mmHg. Systolic blood pressure was not taken into account as an entry criterion.