Pentoxifylline Improves Pulmonary Gas Exchange: RESULTS part 2

2 May
2011

There was a significant increase in the healthy groups exercise Deo (Fig 3), increasing from an average baseline of 36.3 ±3.1 to a maximum of 41.8 ±3.5 ml/min/mm Hg (p<0.001). It then returned toward baseline over the following six weeks. The healthy groups stress test duration, exercise ventila­tion, heart rate, and peak oxygen consumption were not significantly affected by pentoxifylline (Table 3).

Table 3—Exercise Parameters for the Healthy Group

HR Exercise,


Max

Ve,

Vo2 Peak,

Deo max,

Subject

BPM

L/min

ml/min

ml/min/mm Hg

Baseline

1

170

93

3382

38

2

160

76

2322

33

3

161

42

1111

24

4

166

125

3535

47

5

165

74

2426

36

6

173

110

3400

40

12th week of

medication

1

177

103

3365

42

2

164

72

2450

41

3

174

63

1790

27

4

169

125

3775

52

5

163

73

2780

41

6

171

103

3508

48

Both COPD groups showed significant arterial desaturation during exercise (p&lt;0.01). The COPD control groups Soxi0<sub>2</sub> initially fell from 93.0±1.0 percent to 90.5 ± 1 percent when first tested and from 92.3± 1.3 percent to 89.7±1.9 percent 12 weeks later. In the COPD treatment group, Soxi0<sub>2</sub> fell from 92.8 ±1.2 percent to 88.6 ±2.5 percent initially, but from 94.4 ±1.1 percent to only 91.8 ±1.0 percent after 12 weeks of medication. This reduction in desaturation was significant at a level of p&lt;0.05. Viagra Online Canadian Pharmacy

Figure 2. Weekly pulmonary diffusing capacity at rest measured both in the treated patients with COPD and in two representative patients with COPD from the control group. The up arrow indicates the start of pentoxifylline therapy and the down arrow indicates the end of therapy. Gaps in the data reflect missed measurements.

FIGURE 3. Weekly pulmonary diffusing capacity measured in treated healthy subjects within 30 seconds of stopping exercise. The up arrow indicates the start of therapy and down arrow indicates the end of therapy. Gaps in the data reflect missed measurements.

Figure 4 illustrates the most dramatic example of this observation. (This patient was the only one with marked polycythemia). The healthy subjects showed no systematic tendency toward desaturation during exercise.

FIGURE 4. Effect of pentoxifylline on exercising oxygen saturation (measured by oximetry) in a patient with COPD. Supplemental oxygen (2 L of 100 percent 02 by nasal cannula) was required during baseline evaluation.

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