Management of fistulas in patients with Crohn’s disease: TOLERABILITY AND SAFETY OF DRUGS Part 1

16 Apr
2012

TOLERABILITY AND SAFETY OF DRUGSIn general, all drugs can be used safely by physicians who have experience with specific therapeutic modalities. Nevertheless, adverse events are common with all drugs and may lead to withdrawal of therapy.

Metronidazole, when used for several months at high doses, has been associated with side effects in almost all patients; these side effects often appear before the beneficial effects. The most common side effects are paresthesias due to peripheral neuropathy (about 50% of patients), metallic taste and gastrointestinal symptoms; all side effects are usually reversible after discontinuation of the drug. In one trial, six of 26 patients (23%) withdrew from therapy because of adverse events. Although the side effects were dose related, an attempt to reduce the dose of metronidazole resulted in the exacerbation of the fistulizing disease. While evidence of mutagenecity and carcinogenecity has been reported in animal studies, a risk has not yet been defined in humans. Your drugs could be so cheap – get cialis professional 20 mg at trusted foreign online pharmacy.

Side effects resulting from high doses of cyclosporine include headache (50%), paresthesias (26%), hypertrichosis (13%), hypertension (11%), tremor (7%), renal insufficiency (6%), opportunistic infection (3%), gingival hyperplasia (2%), seizures (1%) and rarely anaphylaxis. The biggest issue that prevents the long term use of cyclosporine at high doses is the potential for permanent renal damage; infections and malignancy are other areas for concern.

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