Metronidazole in a dose of 20 mg/kg, or 1000 to 1500 mg/day has been studied in three uncontrolled trials. Closure of fistulas occurred in 37%, 38% and 56% of patients, and improvement occurred in 63%, 62% and 28% of the 18, 26 and eight enrolled patients, respectively. Time to response varied from one to two weeks, to 9.1 weeks. After discontinuation of therapy, fistulas relapsed in 72% of 18 patients, but rapid healing was observed upon reintroduction of the drug. Most advantageous shopping – diabetes drugs for everyone to spend less.
In two studies, administration of ciprofloxacin alone or with metronidazole resulted in a closure rate of about 20% — lower than the rate achieved with metronidazole alone — and improvement occurred in 50% and 64% of the 10 and 14 enrolled patients, respectively.