Archive for the ‘Thrombosis’ Category

Further research should include the use of nonhuman primate or other animal models to study the effects of fish oil on thrombosis and vascular injury as well as the ability of fish oil to inhibit atherogenesis. The possibility that fish oil will hasten regression of established atherosclerosis must be explored in both animals and man. […]

Dietary fish oil or purified preparations of omega-3 fatty acids appear promising as effective antithrombotic or antiatherosclerotic agents for the future. The potential antithrombotic action of fish oil appears to center around its effects on platelets and blood vessel walls. When humans ingest moderate doses of fish oils, the bleeding time is mildly but regularly […]

A second concern has been raised as to the potential carcinogencitiy of long-term fish oil use, perhaps through the formation of oxidation products of the polyunsaturated fatty acids in the fish oil. However, no increase in the cancer rate among Eskimos has been reported, and some animal studies have suggested that fish oil may in […]

Potential Toxicities of Fish Oil Concerns have been raised about the potential toxicity or side effects that might result from the prolonged consumption of fish oil by humans. One such possibility is excessive bleeding, since the Eskimos were said to have frequent epistaxis and easy bruisability. Mild to moderate thrombocytopenia was also found in the […]

However, in those species with atherosclerotic lesions most similar to humans, the effects of omega-3 fatty acids on atherogenesis have generally been beneficial. The effects of omega-3 fatty acids in human atherosclerosis have not yet been studied, but recent preliminary reports have suggested that coronary artery restenosis after angioplasty was reduced in patients given omega-3 […]

Fish Oil and Atherosclerosis The epidemiologic observation that populations which consume substantial quantities of omega-3 fatty acids may have a reduced prevalence of atherothrom-botic cardiovascular disorders led investigators to study the potential inhibitory effects of omega-3 fatty acids on atherogenesis in animals. Weiner et al studied the effects of dietary omega-3 fatty acid supplementation on […]

More recently, Knapp et al studied the effects of fish oil on platelet-vascular interactions as measured by urinary prostaglandin metabolites in patients with advanced atherosclerotic peripheral vascular disease. When fish oil containing 10 g of EPA was administered daily for 4 weeks, elevated levels of urinary TXB2-M fell by almost 60% with only small amounts […]