Archive for the ‘Sepsis’ Category

Myocardial depression in sepsis in humans has been shown to result from circulatory myocardial depressant mediators. Participation of cardiac ischemia has been excluded by studies assessing coronary circulation during sepsis. The prognostic value of myocardial depression in sepsis appears controversial. Whereas a previous report related the risk of a fatal outcome from septic shock due […]

LV hypokinesia in septic shock was first established by Parker et al, working in the Parillo group. These authors also proposed an original concept to explain the recovery of patients with septic shock. They suggested that survival mainly depends on the ability of the left ventricle to dilate owing to volume loading. In their survivors, […]

At day n, LVEDV was 75.4 ± 21.8 mL/m2 and 60.2 ± 21.6 mL/m2 in groups I and II, respectively, still within the normal range. However, LVEDV in group II tended to decrease and remained significantly smaller than in group I. At day 1, LVEF was 43.9 ± 16.4% and 52 ± 14% in groups I and […]

Due to 63% feasibility of transthoracic echocardiography, 90 of the 144 patients with severe sepsis hospitalized over a 5-year period were qualified for our study and underwent serial echocardiographic evaluation. Of these, only 34 recovered and were discharged from our ICU (group I). Fifty-six patients died, resulting in an overall mortality of 62% (group II). […]

Echocardiographic Study Septic Patients: Two-dimensional real-time echocardiographic studies were performed with a wide-angle phased-array digital sector scanner (SONOS 500 K; Hewlett-Packard; Palo Alto, CA). A transthoracic approach via an apical or a left subcostal window was used to obtain a long-axis four-chamber view of the heart. In each patient, the same view was used during serial […]

Circulatory Failure, Hemodynamic Monitoring, and Hemodynamic Support Septic shock was defined as hypotension (systolic arterial pressure < 90 mm Hg by invasive monitoring) despite apparently adequate fluid resuscitation, along with the presence of perfusion abnormalities including oliguria, lactic acidosis (blood lactate level > 2.5 mmol/L), and acute alteration of mental status. All patients also required mechanical ventilation […]

A Longitudinal Echocardiographic Study in Patients With Septic Shock In patients with an episode of septic shock, abnor mal vascular tone was reported by Siegel et al in 1967 and has since been considered as the major hemodynamic consequence of sepsis.2 More recently, some depression of left ventricular (LV) systolic function was recognized, but its meaning […]