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There’s Simply No Room for Error
13, May 2010Problem: When fibrinolytic agents and related drugs are used to treat patients with acute myocardial infarction (AMI), any deviation in the dose, timing, or use of specific agents may adversely affect patient outcomes. However, complex regimens and variations in the way the drugs are dosed and administered increase the chance of serious errors, especially if [...]
Of CABGs and Things
12, May 2010I was under the gun. The editor at MediMedia, publisher of P&T, was rightfully reminding me that I owed her an editorial. As my sense of duty overcame my commitments to other “important matters,” I scrambled to find my folder of potentially “interesting things” to write editorials about. As I sorted through the hodgepodge of [...]
Francis Crick and the Race: James Watson
11, May 2010Crick’s principal collaborator on the structure of DNA was an American, James Watson, one of the most important researchers in the field of genetics. Born in 1928 in Chicago, Illinois, and being a very good student, he enrolled at the University of Chicago when he was only 15 years old and was graduated in 1947. [...]
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Francis Crick and the Race
10, May 2010Introduction
On a typical rainy afternoon in February 1953, Francis Crick walked into his local pub in Cambridge, England, and announced, “We have found the secret of life.”
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BTP is a common cause of hospital admissions and accounts for 4.4% to 7.6% of readmissions. Patients with BTP have higher direct pain-related costs than patients without BTP ($1,080 vs. $750, respectively) and are approximately 2.5 times more likely to seek care in an emergency department than patients with chronic pain but without BTP.
All of the options for BTP can be used in the inpatient setting, but parenteral administration may be less applicable in the outpatient setting. Patients who might be appropriate candidates for parenteral opioid therapy in the outpatient setting include those who are highly motivated to comply with the regimen, are receiving a relatively stable dose [...]
Because the time from onset to peak pain intensity of BTP is generally only a few minutes and the average duration is one-half hour, the opioid that is used to manage most cases of BTP should have a rapid onset of effective analgesia and a duration of action appropriate for the characteristics of the BTP.