Archive for the ‘Lung Disease’ Category

Our results also demonstrated that Dsb, peak Vb2, and ASa(VAVo2 were significantly correlated with clinical ratings of dyspnea. Although most interstitial diseases are associated with restrictive ventilatory defects defined in physiologic terms by decreased lung volumes, data from this study indicated that neither FVC nor TLC was related to the experience of breathlessness in our […]

The data from this investigation increase our understanding of respiratory sensations in ILD. In two previous reports different clinical systems have been described for grading dyspnea during the course of idiopathic pulmonary fibrosis. In addition, psychophysical experiments using both threshold detection and magnitude scaling techniques have been conducted in small numbers of patients with ILD. […]

The mean power function exponent for mouth pressure during elastic loading was similar in patients (1.02 ±0.67) and control subjects (0.74 ±0.71) (p = 0.36) (Fig 1). Because of the wide range of exponents exhibited by the patients, we considered whether two distinct subgroups existed in the ILD patients based on the exponent for added […]

Exercise Testing Eighteen patients performed progressive incremental exercise until limited by exhaustion or by symptoms on the cycle ergometer (Monark-Crescent AB, Varberg, Sweden). Two ILD patients were unable to exercise due to severe dyspnea at rest or joint complaints. Each person breathed through a low-resistance, Hans-Rudolph twoway valve during quiet breathing at rest for 5 […]

Following the presentation of each respiratory load, the subject estimated the perceived magnitude of the sensation by pointing to a number on the Borg category scale. This scale lists phrases of increasing subjective intensity from zero, or “nothing at all,” to ten, or “maximal.” Each elastic load was presented in random order five times. The […]

Clinical Ratings of Dyspnea A modification of the MRC scale, the OCD, and the BDI were used to quantify dyspnea in the patients. The modified MRC scale consists of five grades based on increasing levels of physical activity which provoke breathlessness. After the patients read the descriptive phrases, they selected the grade which best corresponded […]

Materials and Methods Twenty patients with ILD and ten healthy control subjects recruited from employees of the medical center participated in the study. The diagnosis of ILD was based on a chest radiograph showing bilateral interstitial markings and normal heart size, pulmonary function tests, and histologic confirmation of an infiltrative process. The following different types […]