Archive for the ‘Cyclooxygenase’ Category

Animals Tissues were obtained from 16 Angus and Hereford cows from the US Subtropical Agricultural Research Station, Brooksville, FL. Breeding dates were known for some of the cows; in the others, length of gestation was determined from fetal crown-rump length. Samples were obtained at the following gestational ages: 150 days, 275 days, at term not […]

During bovine pregnancy, secretion of estrogen and progesterone increases markedly, potentially leading to induction of COX-2 mRNA expression and PG release. Indeed, from Day 50 onward, OT elicits release of PGF2a in pregnant cows in increasing amounts as gestational age advances. PGF2a is luteolytic in cows; therefore increased production of PGF2a could be detrimental for […]

Prostanoid production in tissues of the reproductive tract is regulated by steroid hormones, but the roles of the individual steroids are not fully understood and seem to vary among species and tissues. In the female, both estrogen and progesterone are involved, apparently in a tissue- and species-specific manner. In the past an association was found […]

Two isoforms of cyclooxygenase enzyme, also known as prostaglandin endoperoxide H synthase, have been identified: cyclooxygenases 1 and 2 (COX-1, COX-2). The two isoforms generate the same prostanoids but are encoded by different genes, which are mapped on different chromosomes and are differently regulated. The genes for each isoform show considerable sequence homology between species […]