We sought to characterize the response to OKT3 administration when this therapy was applied within 72 hours of cardiac transplantation as a part of prophylactic immunosuppression. Despite chest roentgenograms without evidence of pulmonary edema and body weights of within 3 to 4 percent of preoperative weight (although not necessarily dry weight) achieved through the aggressive […]
This hyperdynamic interval ceased before the maximum elevation in temperature that occurred at three hours after the first dose. Reading here The secondary phase, most apparent at five to seven hours after OKT3 administration, was typified by mild hypotension with systemic vasodilation. Concurrently, moderate hypoxemia was present, frequently requiring an increase in supplemental oxygen therapy. […]
Figure 2 illustrates the changes in Sa02 and related variables, including CVP, mean pulmonary arterial pressure, pulmonary arterial occlusion pressure, and PVRI. Relative hypoxemia occurred during the fifth through seventh hours after the dose, as reflected by a decrease in the PaOjj/FlOa ratio. This decrease in PaOz was readily compensated for by an increase in […]
The first dose of OKT3 induced a significant rise in temperature that began within one hour of administration and peaked at three hours (mean temperature, 37.9°C vs 36.8°C before the dose). This increased temperature was still apparent at nine hours after the dose. The cardiovascular response was notable for an early and persistent tachycardia. The […]
All patients were hemodynamically stable prior to OKT3 administration. Serial measurements were made one hour prior to the first dose and at one, three, five, seven, and nine hours after the first dose of OKT3. These measurements included the following: temperature; heart rate; mean arterial blood pressure (arterial line); arterial blood gas levels; SvO, (oximetry); […]
Despite the pioneering technical achievements more than 20 years ago of prominent surgeons including Christian Barnard, Norman Shumway, and Denton Cooley, cardiac transplantation has only recently become a lifesaving procedure with acceptable long-term survival. It has been the concurrent advancement in preservation skills and perioperative and postoperative immunosuppression that is predominantly responsible for this recent success.