Archive for the ‘Bronchoalveolar Lavage Fluid’ Category

In addition, very high lavage type 3 procollagen peptide levels were observed in several sarvoid patients with erythema nodosum or uveitis—clinical combinations which are infrequently associated with the subsequent development of chronic disease and fibrosis. Thus, we found no evidence to suggest that elevated lavage procollagen peptide levels are of prognostic significance in sarcoidosis patients. […]

An association between lavage fibronectin and type 3 procollagen peptide was also noted by Begin et al in patients with asbestosis. Fibronectin, which is produced by the alveolar macrophage, can act as a chemoattractant and competence factor for fibroblasts, drawing them to the site of tissue injury and priming them for proliferation. It is suggested […]

Corticosteroid Treatment To examine the effects of corticosteroid treatment on lavage type 3 procollagen peptide levels, 14 treated patients and eight untreated patients were relavaged. A decrease in median type 3 procollagen peptide levels was observed following treatment (before treatment median, 1.39 and range, 0 to 20.2; after treatment median, 0.54 and range, 0 to […]

Pulmonary Function No correlation was noted between type 3 procollagen peptide levels and indices of pulmonary (unction. Patients with abnormal % FVC or % Dsb levels (<80 percent of predicted normal) had similar type 3 procollagen peptide levels to those with normal % FVC or % Dsb levels. As indicated above, erythema nodosum and uveitis […]

Bronchoalveolar Lavage Analysis Lavage type 3 procollagen peptide levels were above the detection limit of the assay in 45 percent (N = 5) of control subjects and 80 percent (N = 67) of sarcoid patients (Fig 1). Type 3 procollagen peptide levels were significantly elevated in the sarcoid group (p<0.001). However, considerable variation in type […]

Normalization of Lavage Type 3 Procollagen Peptide Levels No satisfactory reference component for normalization of lavage fluid proteins is currently available. Increased leakage of proteins from the capillaries to the alveoli is known to occur in sarcoidosis and this leakage can vary with disease stage and severity. In a situation of capillary-alveolar leakage, type 3 […]

Methods Study Population Eighty four patients (37 women, 47 men) with sarcoidosis verified by biopsy, mean age 33.4 (range 20 to 64) years, underwent bronchoalveolar lavage. Sixty-one were newly presenting at the time of lavage and the median duration of disease from diagnosis in the remaining patients was 33 (range 6 to 126) months. None […]