Archive for the ‘Asthma’ Category

A second type of irritant-induced asthma was not so sudden in onset and embodied features differing from RADS. The causative exposure persisted >24 h, was not brief, and asthma took longer to develop, sometimes days or weeks after repeated exposures. The prevalence of atopy among subjects with the first type (sudden-onset irritant-induced asthma) who were […]

For the 25 individuals with not-so-sudden irritant-induced asthma (^24 h), 10 had a history of preexisting asthma. Characteristically, the irritant exposures of the not-so-sudden asthma case were not massive or single (as for RADS) but were moderate and repeated. Data of 25 subjects with not-so-sudden asthma were as follows: in 9 subjects (36%), asthma developed […]

Information relating the allergic/atopic status to the different types of irritant-induced asthma for 54 cases of irritant-induced asthma showed that 25 of 38 (66%) subjects with new-onset irritant-induced asthma possessed an allergic/atopy predisposition. Of the remaining 16 who suffered an exacerbation of preexisting asthma that was in remission, 12 of 16 (75%) were positive for […]

Subjects in this group, when carefully questioned, recalled previous episodes of asthma, often occurring during childhood or they recalled having been diagnosed as asthmatic by a physician. In other subjects in this group, a strong suspicion of a past asthmatic condition was recognized during the USF examination. Usually, these subjects described an asthmalike process during […]

Yates’ corrected values were used in x2 analyses, and Mantel-Haenzel method and Fisher’s Exact Test were used to test and to explore associations. Odds ratios and the Cornfield 95% confidence limit for the odds ratios were calculated. Relative risks with Taylor series 95% confidence limits for relative risk were estimated and Student’s t tests compared […]

Asthma diagnosis required that three essential clinical features be present: presence of at least three of four typical asthmatic manifestations: (a) episodic cough and/or sputum production; (b) wheezing; (c) nocturnal episodes of cough, wheezing, and breathlessness; and (d) “bronchial irritability,” the patient experiencing respiratory complaints after exposures to various nonspecific irritants, physical factors, and odors; […]

Each subject completed a standardized respiratory questionnaire, underwent direct medical history, and had a physical examination (all performed by S.M.B.). The subject’s medical records were examined for completeness, breadth of information, validity of lung function tests, diagnosis of asthma, criteria establishing “allergic” or atopic status, assessment of exposure considered causative of the asthmatic condition; and, […]