Archive for the ‘Asthma’ Category

These somewhat contradictory results are likely to relate to differences in study populations and study design. Very ill patients with impending respiratory failure may benefit from a larger IV dose initially, whereas the majority of patients are likely to do well without such high doses. Ellul-Micallef and Fenech showed that although hydrocortisone and prednisolone had […]

We compared equivalent amounts of orally and IV administered methylprednisolone and theophylline in the treatment of acute exacerbations of airways obstruction. The patient groups were matched for age, smoking history, and severity of obstruction. We found the two forms of administration equally effective in improving symptomatic as well as spirometric evidence of obstruction in these […]

Twenty-eight patients were entered into the study, and all completed the four days of evaluation. There were 14 in each group and no patient had to be withdrawn because of side effects or lack of response. Three patients in each group had a less than 15 percent increase in FEVj during the study period. These […]

The forced expiratory flow during the middle half of FVC (FEF25-75%) was calculated from the curve with the largest sum of FVC and FEV^ We used the normal values of Morris for all spirometric parameters. Spirometry was thereafter done daily for the duration of the stud); which encompassed the first four days of hospitalization. Peak […]

Intravenous administration of corticosteroids and theophylline has been considered superior to oral use in treating acute episodes of airways obstruction. The intravenous (IV) route is thought to be more reliable, and there is evidence for an earlier onset of steroid action when given IV However, this may not be of clinical importance in the majority […]

Thus, the ventilatory pattern adopted by these asthmatic subjects in response to bronchoconstriction is probably optimal under the circumstances. The ventilatory pattern response to inhaled histamine is believed to be neurally mediated via airway irritant receptors; hypoxemia itself increases respiratory frequency but usually without any decrease in Vt. The ventilatory pattern changes observed after bronchoconstriction […]

In theory, there could be several possible effects of induced bronchoconstriction on the dead space. Firstly, narrowing of the airways could be predicted to decrease airway volume and hence, the anatomic dead space. The present results show that this does not occur: absolute VDan did not alter significantly (Table 1). The reason for this may […]