Archive for the ‘Airways’ Category

Cleavage of Epithelial Glycocalyx Dog tracheal epithelial cells in culture synthesize sulfated macromolecular glycoconjugates and release them from the cell surface upon exposure to extracellular proteinases. In these studies, chymase potently released these glycoconjugates from the epithelial cell glycocalyx. The release of glycoconjugates by chymase provides a mechanism by which mast cell degranulation may affect […]

Airway Smooth Muscle Contraction Hyperresponsiveness to mast cell-derived mediators (eg, histamine) is a distinctive feature of asthma, but its etiology is unknown. We have studied the effects of mast cell enzymes on airway smooth muscle responsiveness. The original studies are described elsewhere. Addition of mastocytoma supernatant to a muscle bath containing dog bronchial smooth muscle […]

Mast cells have been implicated in asthma and in other inflammatory diseases. Multiple physiologic and pathologic effects have been ascribed to mediators that have been shown to be released from these cells, including histamine, prostaglandin D2, leukotrienes, and platelet-activating factor. During degranulation, cells also release tryptic and chymo-tryptic proteases (“tryptases” and “chymases”) extracellularly. These proteases […]