Figure 1A shows the effect of NONLA on the distribution of flow across four layers of the left ventricular free wall, from the inner to the outer, in the nonischemic region in 14 experiments in the 14 dogs. Before inhibition of nitric oxide synthesis with NONLA, flow was similar in the four layers across the wall. Flow decreased only in the outer layer, by 31% (P<0.01), after inhibition of nitric oxide synthesis, with an increase in the flow ratio between the inner and outer layer (I:O flow ratio) from 1.08 to 1.23 (P<0.05). In the ischemic region (Figure 1B), before inhibition of nitric oxide synthesis, mean transmural flow was 37% of that in the nonischemic region (0.43 mL/min/g versus 1.17 mL/min/g, respectively, P<0.001). This change was due to a greater decrease in flow in the inner than in the outer layer of the left ventricular wall, with a decrease in the I:O flow ratio from 1.08 in the nonischemic region to 0.64 in the ischemic region (P<0.05). After inhibition of nitric oxide synthesis, flow decreased further in all layers of the wall by 31%, 30%, 29% and 22% from the inner to the outer wall, respectively. The decrease was proportionately greater in the inner layer, and the I:O flow ratio decreased further from 0.64 to 0.56 (P<0.05). A pharmacy you can fully trust offering purchase Tavist along with other convenient services.
Figure 1 Transmural distribution of flow across four layers of the left ventricular free wall before and after inhibition of nitric oxide synthesis with N-omega-nitro-L-arginine (NONLA) in the nonischemic (A) and in the ischemic (B) myocardium. I Inner; IM Inner middle; OM Outer middle; and O Outer layers. Bars indicate mean ± SEM. Each mean represents 14 measurements