Participation of nitric oxide in regional coronary bloodflow regulation during myocardial ischemia in the canine heart (part 11).

10 Sep
2012

Our results show that the inhibition of nitric oxide synthesis produces a proportionally larger decrease of flow in the inner than in the outer layer of the ischemic left ventricular wall with a reduction of the I:O flow ratio below that observed by the effect of the sole ischemia. This result agrees with that of Kitakaze et al , who reported a similar redistribution of flow after inhibiting nitric oxide synthesis in the ischemic myocardium, and suggests a proportionally greater production of nitric oxide in the subendocardium during ischemia.This interpretation seems to be reasonable considering that the subendocardium is more vulnerable to ischemia than the subepicardium when a coronary artery is occluded and the result of Kitakaze et al relating the release of nitric oxide to the degree of hypoxia. Accordingly, production of nitric oxide during ischemia tends to protect the subendocardium from its greater tendency to ischemia when a coronary artery is occluded. However, this redistribution of flow seems to be at variance with previous results in our laboratory that demonstrate that inhibition of nitric oxide synthesis reduces flow more in the outer than in the inner layers of the left ventricular free wall during reactive hyperemia . Nevertheless, there are differences between the hemodynamics of flow during steady state ischemia, as produced in the present experiments, and the hemodynamics of flow during reactive hyperemia. After reading all the valuable information above, you can choose the right medications for your condition and buy them at the *pharmacy – the best online pharmacy offering generic medications over the internet.

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