Effects of the antiarrhythmic agent tedisamil on cardiac potassium currents in humans (part 1)

18 Aug

currents in humans (part 1)

The major potassium currents detected in human ventricular myocytes are the transient outward current (Ito) and the inward rectifier Ik1, while the delayed rectifier Ik is difficult to detect . In atrial myocytes an additional current, the sustained outward current (Iso), can be distinguished . Antiarrhythmic drugs that prolong the action potential duration may affect any of these repolarizing currents. Growing interest in this class of antiarrhythmic drugs has led to a large number of newly developed agents, including almokalant and tedisamil.Almokalant is a selective blocker of the rapidly activating component of the delayed rectifier Ikt in guinea pig ventricular myocytes . Tedisamil was originally developed as an anti-ischemic drug and was later shown to block several potassium currents, including Ito in rat and Ik in guinea pig ventricular myocytes . Because all of these agents were developed for the treatment of diseased human patients, it is necessary to investigate their effects on repolarizing membrane currents of human cardiac myocytes. Therefore, the aim of the present study was to characterize the effects of tedisamil on Iso and Ito in human cardiac myocytes.
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