By the beginning of October 1999, 101 confirmed and presumed cases of intussusception had been reported to VAERS. The rate of reporting increased greatly after the July 1999 announcement of the temporary postponement of rotavirus vaccination. Fifty-two patients required surgery, nine required bowel resection and one patient died. Fifty-seven of these children developed intussusception within [...]
Rotavirus vaccine withdrawal in the United States: The role of postmarketing surveillance n August 31, 1998, Rotashield (Wyeth Laboratories, Marietta, Pennsylvania) was licensed by the United States Food and Drug Administration for oral administration to infants at two, four and six months of age in the United States. This product is a live, attenuated rhesus [...]
Our survey demonstrates that the risk of nosocomial blood stream infections has nearly doubled for patients admitted to our hospital between 1986 and 1996, as a result of small but relentless increases from 1986 to 1995, followed by a large increase between 1995 and 1996. Because our surveillance technique, definitions of infection and number of [...]
There were 2389 episodes of nosocomial blood stream infection between August 1, 1986 and December 31, 1996. The annual number of cases gradually rose from 184 in 1987, the first full year of the survey, to 267 in 1996. The case rate similarly rose from 6.0/10,000 admissions in 1986 to 8.7/10,000 admissions in 1995 (Figure [...]
The University of Alberta Hospital is a tertiary acute care facility and principal teaching hospital of the University of Alberta Faculty of Medicine. All forms of acute medical care were provided during most of the survey period, including adult and paediatric medicine and surgery, obstetrics/gynecology, hematological oncology, and solid organ transplantation. The hospital has seven [...]
Long term trends in the occurrence of nosocomial blood stream infection Hospital care has long been associated with development of nosocomial infection. Recently, these infections have been identified as a significant public health problem. Changes in health care delivery over time, including the increased use of invasive procedures or immunosuppressive therapy in hospitalized patients and, [...]
Health care restructuring in 1995 radically transformed our hospital, with a resultant impact on nosocomial blood stream infections. While there was a decrease in bed number, admissions and patient days at the hospital, patient populations shifted from groups at lower nosocomial infection risk (eg, ophthalmology, psychiatry, internal medicine and paediatrics) to groups at higher risk [...]