Archive for February, 2011

INTRODUCTION Merkel cell carcinoma (MCC), also referred as neuroendocrine or trabecular carcinoma, is an uncommon malignancy originally described by Toker in 1972. Although the exact origin of the Merkel cell is unknown, it probably arises from neuro¬endocrine cells between the basal epidermis and then grows vertically into the dermis and sub¬cutaneous tissue. It usually arises [...]

Ultrastructural analysis shows tumor cells closely apposed to each other by continuous basal laminae and rudimentary cell junctions. Cells show abundant cytoplasm containing numerous mitochondria and aggregates of glycogen.

Clear cell sarcoma (CCS), first described by Enzinger in 1965, is a rare soft tissue tumor. Before this, this uncommon neoplasm had been misdi- agnosed as fibrosarcoma, synovial sarcoma, heman-SJ Jung, et al. giopericytoma, alveolar soft-part sarcoma, and hemangioendothelioma. It occurs most frequently in the feet and ankles of women in the second and third [...]

A 57-year-old female visited our clinic with a chief complain of a skin lesion on her right lower abdomen of two years duration. She had a mitral valve replacement surgery 5 years ago, and is now taking warfarin for maintenance therapy. Other than this, there is nothing special in her past medical or family history. [...]

INTRODUCTION Clear cell sarcoma is a rare malignant soft tissue neoplasm that usually arises adjacent to tendons or aponeuroses. It generally affects young adults with a predominance in women and mostly appears in the extremities, especially the feet and ankles. The clinical course is rather slow, with repeated local recurrences followed by late metastases and [...]

Epidemiologic studies have shown an inverse relationship between presence of various cancers and dietary carotenoids or blood carotenoid levels. However, several trials using в-carotene supple­ments did not show protective effects against cancer or cardiovascular diseases. On the contrary, the high risk population (smokers and asbestos workers) in these trials showed an increase in cancer and [...]

Onychodystrophy implies various pathologic pro­cesses of the nails including infectious and noninfectious disorders such as onychomycosis, psoriasis, and allergic and irritant dermatitis. Nail changes may also be a clue to other dermatological or systemic diseases. However, chronic idiopathic onychodystrophy is often seen without any associ­ated conditions and onycholysis and onychorrhexis are two of the most [...]

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