Cutaneous metastasis from neuroendocrine car­cinoma of visceral origin is rarely described. The primary sites of origin include the lungs, larynx, mediastinum, uterus, and thymus. Histologically, a rosette-like structure is regarded as the best marker for recognition of neuroendocrine differentiation and is described as a small and regular, oval or round lumina, deeply eosinophilic luminal surfaces, [...]

A 58-year-old man presented with 1-month history of several skin lesions on his scalp, which had started as a tiny skin-colored papule. This progressively enlarged to form a solitary 2 cm-sized tender tumor and several new lesions had de­veloped. He had a history of rectal neuroendocrine carcinoma with multiple hepatic metastases.

INTRODUCTION Neuroendocrine neoplasm have been described in virtually every organ where neuroendocrine cells are distributed throughout the body. It com­monly exhibits multiple lines of divergent differen­tiation. Metastatic neuroendocrine carcinoma from distant sites, such as lung, and colon are high degrade tumors with poor prognosis. Cutaneous metastatic neuroendocrine carcinoma must be differentiated from Merkel cell carcinoma [...]