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Archive for March, 2010
Follicular hyperkeratinization underlies the development of comedones, the characteristic acne lesion. Although many patients believe that acne stems from a failure to clean the face effectively and sufficiently, researchers have noted it is a failure of the skin and the pores to slough off dead skin cells. Hyperkeratinization is related to the presence of P. [...]
- In: Acne
- Tags: Acne, Acne Diagnosis, Acne Treatment
Differential Diagnosis The differential diagnosis of acne includes gram-negative fol-liculitis, perioral dermatitis, sebaceous hyperplasia, syringoma, tuberous sclerosis (adenoma sebaceum), trichoepithelioma, Demodex folliculitis, bacterial folliculitis, and papular sarcoido-sis. The diseases that most closely resemble acne, but are said to be distinguishable from it, include: gram-negative folliculitis: occurs after months of therapy with tetracycline (e.g., Sumycin, Par); [...]
- In: Acne
- Tags: Acne, Acne Diagnosis, Acne Treatment
Acne: A Review of Diagnosis and Treatment
5, Mar 2010Abstract Acne vulgaris (acne) is probably the most common derma-tological complaint in the U.S. Acne has a range of presentations and manifestations, thus apparently comprising many disease states. Although acne is not an infectious disease, specimens of bacteria such as Propionibac-terium acnes, Propionibacterium granulosus, and Staphylococcus epidermidis can be obtained for culture from the eruptions [...]
- In: Acne
- Tags: Acne, Acne Diagnosis, Acne Treatment
Ramelteon is a melatonin receptor agonist. According to the manufacturer, its molecular structure is composed of a substituted tetrahydroindenofuran derivative containing a propionamide moiety with one chiral center, and the compound is produced as the (S) enantiomer. It is freely soluble in organic solvents and is considered very slightly soluble in water or aqueous buffers [...]
Ramelteon (Rozerem): DOSAGE
3, Mar 2010Adults The recommended dose of ramelteon is 8 mg, taken within 30 minutes of bedtime. Ramelteon should not be taken with, or immediately after, a high-fat meal because of the delay in absorption. Elderly Patients No overall differences in safety or efficacy were observed between elderly and younger adult subjects. In a phase 3 study [...]
Ramelteon (Rozerem): ADVERSE DRUG EFFECTS
2, Mar 2010The adverse drug events (ADEs) associated with ramelteon appear to be minor and similar to those of placebo. Of the 3,594 subjects evaluated in the phase 1 to phase 3 studies of ramelteon, the most frequent ADEs leading to discontinuation were somnolence (0.8%), dizziness (0.5%), nausea (0.3%), fatigue (0.3%), headache (0.3%), and insomnia (0.3%). Of [...]
Ramelteon (Rozerem): Roth et al.
1, Mar 2010A double-blind study by Roth and colleagues evaluated the efficacy of ramel-teon in treating transient insomnia in healthy adults ranging from 35 to 60 years of age. Subjects received 16 mg, 64 mg, or placebo 30 minutes before bedtime. The study enrolled 375 patients from 14 sleep research centers in the U.S. The investigators used [...]