Four published clinical trials have assessed the efficacy and safety of rimonabant in the treatment of obesity and cardiometabolic risk factors. Other studies of the drug have been presented as posters at clinical meetings, but they are not reviewed in this article. The iSmonabant In Obesity (RIO) Program consists of four published clinical trials comparing [...]

Rimonabant [,/V-piperino-5-(4-chloro-phenyl)-1-1(2,4-dichlorophenyl)-4-meth-ylpyrazole-3-carvoxamide] is a CB1 antagonist. At low concentrations, it may also act as an inverse agonist.8 At very high concentrations, canadian rimonabant also behaves as a CB2 receptor antagonist, blocks calcium and potassium channels, and may directly affect cellular gap junctions. Cannabinoid receptors are members of the G-protein coupled receptor (GPCR) superfamily of cell-surface [...]

INTRODUCTION The prevalence of obesity continues to rise. Current data indicate that the combined prevalence of overweight and obesity in adults in the U.S. is 66.3%. The prevalence for obesity alone in adults is 32.2%; for extreme obesity in adults, this figure is 4.8%. Approximately 17.1% of children and adolescents in the U.S. are overweight. [...]