Osteoarthritis (OA) is a non-inflammatory disease characterized by progressive loss of joint articular cartilage that results in pain and deformity. The disease is also known as degenerative arthritis, degenerative joint disease (DJD), and osteoarthrosis. Epidemiologic data on OA varies depending on the source but the general consensus is that it is the most common joint [...]
Ganciclovir, a synthetic acyclic nucleotide analog of guanine, is phosphorylated to a triphosphate within the cell and acts as an inhibitor of viral DNA synthesis. Preliminary data have shown ganciclovir effective in the treatment of symptomatic congenital CMV infection. A phase II study with ganciclovir showed hearing improvement or stabilization in five of 30 infants [...]
CMV infection can be diagnosed by isolation of the virus from the urine or saliva within the first three weeks of life. This can be accomplished by traditional virus culture methods which may take one to two weeks to obtain a result or rapid culture methods (”shell vial assay”) using centrifugation to enhance infectivity and [...]